What are histone deacetylase inhibitors?

OVERVIEW:

Histone deacetylase inhibitors (HDIs) are the chemical compounds that inhibit histone deacetylase.

Histone deacetylases (HDACs) enzymes removes acetyl group from the ε-amino groups of lysine residues which are located in the NH2 terminal tails of core histones.

During gene expression DNA coils and uncoils around histones. Histone acetylases, acetylate the lysine residues in core histones and histone deactylases remove the acetyl groups from the lysine residues. It plays an important in the gene expression.

Histone deacetylase inhibitors prevent the deactylation that affects gene expression. It may leads to apoptosis of tumor cells.

USES OF HISTONE DEACETYLASE INHIBITORS :

HDIs are used to stabilize mood and anti-epileptics. Therefore, it plays an important role in neurology and psychiatry.

They are used in treatments for cancers, inflammatory diseases etc.

These compounds are used as anticancer agents. It induces differentiation, cell-cycle arrest, and apoptosis that inhibits migration, angiogenesis etc. in many cancer cells

They inhibit growth of tumor growth in animal models and thus show antitumor activity in patients.

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