During which stage of the cell cycle does DNA replication occur?

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    DNA is replicated during the S phase (Synthesis phase) of Interphase. Interphase is basically the daily life cycle of the cell. Cells spend most of their life in Interphase before Mitosis occurs (M phase). Interphase generally lasts at least 12 to 24 hours in mammalian tissue. Interphase can be divided into 4 steps: - Gap 0 (G0) - Gap 1 (G1) - S (synthesis) phase - Gap 2 (G2). Gap 0 (G0): Sometimes cell leave the cycle and quit dividing. This may be a temporary resting period or more permanent. Gap 1 (G1): Cell cycle control mechanism activated during this period called as G1 Checkpoint to ensure everything is ready for DNA synthesis. S Phase: To produce two similar daughter cells, the complete DNA instructions in the cell must be duplicated. DNA replication occurs during this S (synthesis) phase. Gap 2 (G2): Another cell cycle control mechanism activated during this period (G2 Checkpoint) to determine if the cell can now proceed to enter M (mitosis) and divide.

    • 06 Dec 2017 @ 08:29


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What kinds of chromosomal rearrangements can lead to gene dose deleterious effects in 3) individuals that carry them? A) duplications B) deletions C) inversions D) reciprocal translocations E) A and B are correct.

Answer is: E) A and B are correct Gene dosage is defined as number of times a given gene is present in the nucleus of cell. Imbalance in gene dosage alter the amount of a particular protein relative to all other proteins, and lead to variety of phenotypic effects. Deletion causes loss of part of a chromosome that results on monosomy for that segment of the chromosome. Duplication results in doubling of part of a chromosome, resulting in trisomy for that segment. Thus, gene dosage result is either decrease or increase in that part of a chromosome...